A mechanical model of neuron axons considering extracellular matrix stiffness

The extracellular matrix plays a key role in the development and regeneration of the nervous system, and abnormal changes in its mechanical properties are related to the occurrence of neurological diseases. are closely related to development. Neurons use their axon terminal growth cones to sense the mechanical properties of the extracellular matrix, and then produce directional migration behavior. This article establishes a cell A cell adhesion-dependent axon mechanical model was used to explore the molecular mechanism by which extracellular matrix stiffness affects the directional migration behavior of neurons. By describing the cell adhesion Dynamic processes such as attachment-dissociation process, actin activation-contraction and axon growth characterize the relationship between nerve axons, growth cones and extracellular matrix. The mechanical interaction process between different types of neurons. The theoretical results reveal the molecular mechanism of the differences in force-sensitive behaviors of different types of neurons, and clarify the influence of matrix stiffness on Influence rules of nerve axon growth. In summary, this article establishes a nerve axon mechanical model to study the physiological behavior of neurons in sensing the stiffness of the extracellular matrix. It provides a quantitative description and describes the "axon-growth cone-extracellular matrix" interaction process from a mechanical perspective, providing a potential theory for nerve regeneration and repair. in accordance with.