Chinese Science Bulletin

The promoter-proximal pause induced by the binding of the DRB sensitivity-inducing factor (DSIF) and the negative elongation factor (NELF) to RNAP II is a key step in the regulation of metazoan gene expression. It helps maintain a permissive chromatin landscape and ensures a quick transcriptional response from stimulus-responsive pathways such as the innate immune response. It is also involved in the biology of several RNA viruses such as the human immunodeficiency virus (HIV), the influenza A virus (IAV) and the hepatitis delta virus (HDV). HIV uses the pause as one of its mechanisms to en

Gas sensing holds great significance in environment monitoring, real–time security alerts and clinical diagnosis, which require sensing technology to distinguish various target molecules with extreme sensitivity and selectivity. Surface–enhanced Raman spectroscopy (SERS) has great potential in gas sensing for its single molecule sensitivity and fingerprint specificity. However, different from molecule sensing in solutions, SERS detection of gas often suffers from low sensitivity as gas molecules usually display a low Raman cross–section and poor affinity on traditional nob

Vitamin E is easily oxidized by light, air, oxidizing agents and heat, limiting its application in many ways. Compared to vitamin E, vitamin E ester derivatives exhibit improved stability and a stronger antioxidant capacity, and even gain new biological functions. In recent years, enzymatic synthesis of vitamin E ester derivatives has received increasing attention due to its environmental friendliness, high catalytic efficiency, and inherent selectivity. This paper reviews the related progress of lipase-mediated preparation of vitamin E ester derivatives. The function of different vitamin E

The El Niño–Southern Oscillation (ENSO) is the strongest interannual air–sea coupled variability mode in the tropics, and substantially impacts the global weather and climate. Hence, it is important to improve our understanding of the ENSO variability. Besides the well-known air–sea interaction process over the tropical Pacific, recent studies indicated that atmospheric and oceanic forcings outside the tropical Pacific also play important roles in impacting and modulating the ENSO occurrence. This paper reviews the impacts of the atmosphere–ocean variability o

The accurate modeling of frequency-dispersive materials is a challenging task, especially when a scheme with a transient nature is utilized, as it is the case of the finite-difference time-domain method. In this work, a novel implementation for the modeling of graphene-oriented dispersive materials via the piecewise linear recursive convolution scheme, is introduced, while the time-varying conductivity feature is, additionally, launched. The proposed algorithm is employed to design a reduced graphene-oxide antenna operating at 6 GHz. The transient response to graphene’s conductivity v